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Prof. Vladimir Khavinson
Peptide bioregulators are the future of medicine

Patents

Patent №
Title
Authors
Country, year of issue
1
CH 659586
Arzneimittel aus dem Thymus und Verfahren zu dessen Herstellung.
(Pharmaceutical substance from thymus gland and method for producing the same)
Morozov V.G. Khavinson V.Kh.
Switzerland and Liechtenstein 13.02.1987
2
DE 3421789
Arzneimittel auf der Basis einer Thymusfraktion und Verfahren zu dessen Herstellung.
(Thymus-gland substance and method for producing the same)
Morozov V.G. Khavinson V.Kh.
Germany, 06.10.1988
3
Fr 2583982
Produit medicamenteux obtenu a partir du thymus et son procede d'obtention.
(Thymus-gland substance and method for producing the same)
Morozov V.G. Khavinson V.Kh.
France, 24.02.1989
4
JP 1625201
Process for Production of Thymus Gland Preparation.
Morozov V.G. Khavinson V.Kh.
Japan, 18.11.1991
5
US 5,070,076
Thymus-Gland preparation and method for producing same.
Morozov V.G. Khavinson V.Kh
USA, 03.12.1991
6
AU 616236
Pharmaceutical preparation for treating immunodeficiency conditions.
Yakovlev G.M. Morozov V.G. Khavinson V.Kh. Deigin V.I. Korotkov A.M.
Australia, 03.03.1992
7
EP 0346501
Arzneimittelzubereitung zur behandlung des immunmangels.
(Pharmaceutical preparation for therapy of immunodeficit states)
Yakovlev G.M. Morozov V.G. Khavinson V.Kh. Deigin V.I. Korotkov A.M.
European patent, 29.07.1992
8
BY 140
Иммуностимулирующее средство «Тимоген». (Immunostimulating substance “Timogen”)
Yakovlev G.M. Morozov V.G. Khavinson V.Kh. Deigin V.I. Korotkov A.M.
Belarus, 26.10.1993
9
CА 1,330,300
Pharmaceutical preparation for therapy of immunodeficit states.
Yakovlev G.M. Morozov V.G. Khavinson V.Kh. Deigin V.I. Korotkov A.M.
Canada, 21.06.1994
10
LV 5407
Imьnstimulejoљs lidzeklis “TIMOGEN”.(Immunostimulating substance “Timogen”)
Yakovlev G. Morozov V. Khavinson V. Deigin V. Korotkov A.
Latvia, 10.03.1994
11
LT 2498
"TIMOGEN".(Immunostimulating substance “Timogen”)
Deigin V. KorotkovA. Khavinson V. Yakovlev G.
Lithuania, 27.04.1994
12
UA 7130
Iмуностимулюючий засiб «Тiмоген». (Immunostimulating substance “Timogen”)
Yakovlev G.M. Morozov V.G. Khavinson V.Kh. Deigin V.I. Korotkov A.M.
Ukraine, 30.06.1995
13
JP 2511159
Pharmaceutical preparation for treating immunodeficiency conditions.
Yakovlev G.M. Morozov V.G. Khavinson V.Kh. Deigin V.I. Korotkov A.M.
Japan, 26.06.1996
14
US 5,538,951
Pharmaceutical preparation for the therapy of immune deficiency conditions.
Morozov V.G. Khavinson V.Kh.
USA, 23.07.1996
15
US 5,728,680
Methods for normalizing numbers of lymphocytes.
Morozov V.G. Khavinson V.Kh.
USA, 17.03.1998
16
US 5,767,087
Pharmaceutical preparation for the therapy of immune deficiency conditions.
Morozov V.G. Khavinson V.Kh.
USA, 16.06.1998
17
US 5,770,576
Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity.
Morozov V.G. Khavinson V.Kh.
USA, 23.06.1998
18
US 5,789,384
Pharmaceutical dipeptide compositions and methods of use thereof.
Khavinson V.Kh. Sery S.V. Morozov V.G.
USA, 04.08.1998
19
US 5,807,830
Method for treatment of purulent inflammatory diseases.
Morozov V.G. Khavinson V.Kh.
USA, 15.09.1998
20
US 5,811,399
Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants.
Khavinson V.Kh. Morozov V.G.
USA, 22.09.1998
21
US 5,814,611
Pharmaceutical for the therapy of immune deficiency conditions.
Morozov V.G. Khavinson V.Kh.
USA, 29.09.1998
22
US 6,066,622
Immunomodulating peptides and methods of use.
Green L.R. Sinackevich N.V. Ivanov V.T. Mikhalyova I.I. Vaskovsky B.V. Mikhaltsov A.N. Khavinson V.Kh. Morozov V.G.
USA, 23.05.2000
23
US 6,100,380
Immunomodulating peptides and methods of use.
Green L.R. Sinackevich N.V. Ivanov V.T. Mikhalyova I.I. Vaskovsky B.V. Mikhaltsov A.N. Morozov V.G. Khavinson V.Kh.
USA, 08.08.2000
24
US 6,136,788
Pharmaceutical preparation for the therapy of immune deficiency conditions.
Morozov V.G. Khavinson V.Kh
USA, 24.10.2000
25
US 6,139,862
Pharmaceutical dipeptide compositions and methods of use thereof.
Khavinson V.Kh. Sery S.V. Morozov V.G.
USA, 31.10.200
26
US 6,346,514
Pharmaceutical lysine-containing polypeptide compositions and method of use thereof.
Green L.R. Sinackevich N.V. Ivanov V.T. Mikhalyova I.I. Vaskovsky B.V. Mikhaltsov A.N. Khavinson V.Kh. Morozov V.G.
USA, 12.02.2002
27
US 6,368,788
Method of treating complications in immunodepressed states resulting from HIV infection.
Kozhemyakin A.L. Sinackevich N.V. Seryi S.V. Rakhilov A.M. Morozov V.G. Khavinson V.Kh.
USA, 09.04.2002
28
СH 692477
Zusammensetzung zur Stimulation von Wiederherstellungsvorgдngen, enthaltend L-Lysil-L-Glutaminsдure.
(Application of dipeptide L-Lys-L-Glu for stimulation of reparative processes)
Khavinson V.Kh. Morozov V.G. Malinin V.V. Sery S.V.
Switzerland and Liechtenstein, 15.07.2002
29
EP 1224212
Tetrapeptide stimulating functional activity of neurones, pharmacological agent based thereon and method of use thereof.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Grigoriev E.I.
European patent, 09.07.2003
30
ЕР 1089753
Use of a dipeptide for stimulating repair processes.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Sery S.V.
European patent, 23.07.2003
31
US 6,642,201
Use of a dipeptide for stimulating repair processes.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Sery S.V.
USA, 04.11.2003
32
US 6,727,227
Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application.
Khavinson V.Kh.
USA, 27.04.2004
33
US № 6,777,195
Phharmaceutical dipeptide compositions and method of use thereof: immunostimulants.
Kozhemyakin A.L. Sinackevich N.V. Seryi S.V. Rakhilov A.M. Morozov V.G. Khavinson V.Kh.
USA, 17.08.2004
34
ЕР 1325026
Tetrapeptide stimulating functional activity of hepatocytes and its therapeutical use.
Khavinson V.Kh.
European patent, 18.08.2004
35
ЕР 1353939
Tetrapeptide regulating prostate functions and its compositions and uses.
Khavinson V.Kh. Malinin V.V. Grigoriev E.I.
European patent, 25.08.2004
36
AU 769847
Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application.
Khavinson V.Kh.
Australia, 20.05.2004
37
DK 175381
Farmaceutisk pr?parat til behandling af immundefekttilstande.
(Pharmaceutical preparation for treating immunodeficiency conditions)
Yakovlev G.M. Morozov V.G. Khavinson V.Kh. Deigin V.I. Korotkov A.M.
Danmark, 20.09.2004
38
AU 776693
Use of a dipeptide for stimulating repair processes.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Sery S.V.
Australia, 06.01.2005
39
ЕР 1179008
Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application.
Khavinson V.Kh.
European patent, 22.03.2006
40
AU 784578
Tetrapeptide stimulating functional activity of neurones, pharmacological agent based thereon and method of use thereof.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Grigoriev E.I.
Australia, 17.08.2006
41
US 7,101,854
Tetrapeptide stimulating the functional activity of hepatocytes, pharmacological substance on its basis and the method of its application.
Khavinson V.Kh.
USA, 05.09.2006
43
US 7,189,701
Tetrapeptide stimulating functional activity of neurons, pharmacological agent based thereon and method of use thereof.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Grigoriev E.I.
USA, 13.03.2007
44
LV 13462
Cukuralоmeni asinоs regulзjoрs tetrapeptоds cukurslimоbas вrstзрanai. (Tetrapeptide regulating glucose level in case of diabetes mellitus)
Khavinson V.Kh. Malinin V.V. Grigoriev E.I. Ryzhak G.A.
Latvia, 20.02.2007
45
СА 2,373,128
Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application.
Khavinson V.Kh.
Canada, 13.03.2007
46
LT 5421
Tetrapeptidas, reguliuojantis kraujo gliukozлs lygi, sergant cukriniu diabetu.
(Tetrapeptide regulating glucose level in case of diabetes mellitus)
Khavinson V.Kh. Malinin V.V. Grigoriev E.I. Ryzhak G.A.
Lithuania, 25.05.2007
47
ЕА 008541
Tetrapeptide regulating glucose level in case of diabetes mellitus.
Khavinson V.Kh. Malinin V.V. Grigoriev E.I. Ryzhak G.A.
Eurasia, 29.06.2007
48
IL 146432
Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application.
Khavinson V.Kh.
Israel, 04.09.2007
49
IL 140412
L-LYS-L-GLU dipeptides for pharmaceutical preparations.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Sery S.V.
Israel, 17.09.2007
50
ЕР 1758922
Peptide substance restoring function of respiratory organs.
Khavinson V.Kh. Ryzhak G.A. Grigoriev E.I. Ryadnova I.Yu.
European patent, 13.02.2008
51
ЕР 1758923
Peptide substance restoring myocardium function.
Khavinson V.Kh. Ryzhak G.A. Grigoriev E.I. Ryadnova I.Yu.
European patent, 13.02.2008
52
ЕА 010156
Peptide stimulating liver tissue regeneration, pharmacological substance based thereon and method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Eurasia, 30.06.2008
53
ЕА 010157
Peptide stimulating neurones regeneration, pharmacological substance based thereon and method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Eurasia, 30.06.2008
54
ЕА 010158
Peptide enhancing capillary resistancy, pharmacological substance based thereon and method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Eurasia, 30.06.2008
55
ЕА 010573
Gepatoprotective substance and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
56
ЕА 010574
Peptide normalizing osseous and cartilaginous tissue metabolism, pharmacological substance based thereon and method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
57
ЕА 010575
Peptide revealing immuno geroprotective effect, pharmacological substance based thereon and method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
58
ЕА 010720
Method for obtaining the substance revealing tissue specific activity for supporting therapy, pharmacological substance produced thereby.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
59
ЕА 010722
Pharmaceutical substance normalizing urinary bladder tonus and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
60
ЕА 010723
Pharmaceutical substance normalizing kidneys functions and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
61
ЕА 010724
Pharmaceutical substance normalizing cartilaginous tissue functions and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
62
ЕА 010734
Pharmaceutical substance normalizing blood vessels functions and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
63
ЕА 010735
Pharmaceutical substance normalizing male reproductive function and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
64
ЕА 010736
Pharmaceutical substance normalizing female reproductive function and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
65
ЕА 010737
Pharmaceutical substance revealing geroprotective activity and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
66
ЕА 010738
Pharmaceutical substance normalizing thyroid gland functions and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
67
ЕА 010739
Pharmaceutical substance normalizing brain functions and method for producing the same.
Khavinson V.Kh. Malinin V.V. Ryzhak G.A.
Eurasia, 30.10.2008
68
ЕА 011092
Peptide revealing stress protective effect, pharmacological substance based thereon and method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Eurasia, 30.12.2008
69
UA 85204
Тетрапептид, що регулює рiвень глюкози в кровi при цукровому дiабетi. (Tetrapeptide regulating glucose level in case of diabetes mellitus)
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Ukraine, 12.01.2009
70
US 7,491,703
Tetrapeptide regulating blood glucose level in diabetes mellitus.
Khavinson V.Kh. Malinin V.V. Grigoriev E.I.v Ryzhak G.A.
USA, 17.02.2009
71
ЕР 2024388
Peptide substance stimulating regeneration of central nervous system neurons, pharmaceutical composition on its base, and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
European patent, 14.10.2009
72
ЕР 2024387
Peptide substance enhancing capillaries resistance, pharmaceutical composition on its base and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
European patent, 21.10.2009
73
US 7,625,870
Peptide substance restoring respiratory organs function.
Khavinson V.Kh. Ryzhak G.A. Grigoriev E.I. Ryadnova I.Yu.
USA, 01.12.2009
74
ЕР 1697401
Tetrapeptide regulating blood glucose level in diabetes mellitus.
Khavinson V.Kh. Malinin V.V. Grigoriev E.I. Ryzhak G.A.
European patent, 06.01.2010
75
US 7,662,789
Peptide substance restoring myocardium function.
Khavinson V.Kh. Ryzhak G.A. Grigoriev E.I. Ryadnova I.Yu.
USA, 16.02.2010
76
JP 4489946
Use of a dipeptide for stimulating repair processes.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Sery S.V.
Japan, 09.04.2010
77
UA 91135
Пептид, що має iмуногеропротекторну дiю, фармацевтична композицiя на його основi i спосiб її застосування. (Peptide substance revealing an immunogeroprotective effect, pharmaceutical composition on its base and the method of its application.)
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Ukraine, 25.06.2010
78
UA 91136
Пептид, що стимулює регенерацiю нейронiв центральної нервової системи, фармацевтична композицiя на його основi i спосiб її застосування.
(Peptide substance stimulating regeneration of central nervous system neurons, pharmaceutical composition on its base, and the method of its application.)
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Ukraine, 25.06.2010
79
UA 91137
Пептид, що пiдвищує резистентнiсть капiлярiв, фармацевтична композицiя на його основi i спосiб її застосування.
(Peptide substance enhancing capillaries resistance, pharmaceutical composition on its base and the method of its application.)
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Ukraine, 25.06.2010
80
AU 2004296269
Tetrapeptide regulating blood glucose level in diabetes mellitus.
Grigoriev E.I. Khavinson V.Kh. Ryzhak G.A. Malinin V.V.
Australia, 16.09.2010
81
UA 92387
Пептид, що має стреспротекторну дiю, фармацевтична композицiя на його основi i спосiб її застосування.
(Peptide substance revealing a stress protective effect, pharmaceutical composition on its base and the method of its application.)
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Ukraine, 25.10.2010
82
US 7,851,449
Peptide, pharmaceutical composition, and a method of treating microcirculation disorders.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
USA, 14.12.2010
83
CA 2,425,445
Tetrapeptide stimulating functional activity of hepatocytes, pharmacological substance on its basis and the method of its application.
Khavinson V.Kh.
Canada, 18.01.2011
84
JP 4668497
Tetrapeptide stimulating functional activity of neurons, pharmacological agent based thereon and method of use thereof.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Grigoriev E.I.
Japan, 13.04.2011
85
IN 247551
Tetrapeptide lisyl-glutamyl-aspartyl-tryptophane amide.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
India, 19.04.2011
86
EP 2032595
Peptide substance revealing an immunogeroprotective effect, pharmaceutical composition on its base and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
European patent, 22.06.2011
87
UA 62779
Спосiб лiкування первинної вiдкритокутової глаукоми. (Method of treatment of the primary open-angle glaucoma.)
Panchenko M.V. Khavinson V.Kh. Ryzhak G.A. Panchenko O.M. Samofalova M.M. Alekseenko K.A. Yakubovich N.V.
Ukraine, 12.09.2011
88
US 8,057,810
Peptide substance revealing an immunogeroprotective effect, pharmaceutical composition on its base and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
USA, 15.11.2011
89
CA 2,547,873
Tetrapeptide regulating blood glucose level in diabetes mellitus.
Khavinson V.Kh. Malinin V.V. Grigoriev E.I. Ryzhak G.A.
Canada, 22.11.2011
90
US 8,071,556
Peptide substanse revealing a stress protective effect, pharmaceutical composition on its base and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
USA, 06.12.2011
91
KR 10-1106609
Tetrapeptide regulating blood glucose level in diabetes mellitus.
Khavinson V.Kh. Malinin V.V. Grigoriev E.I. Ryzhak G.A.
South Korea, 10.01.2012
92
CA 2,335,362
Use of a dipeptide for stimulating repair processes.
Khavinson V.Kh. Morozov V.G. Malinin V.V. Sery S.V.
Canada, 20.11.2012
93
IL 194346
Tripeptide having a stimulating effect on the regeneration of neurons and pharmaceutical composition it.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Israel, 01.04.2013
94
KR 10-1289220
Peptide substance stimulating regeneration of central nervous system neurons, pharmaceutical composition on its base, and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
South Korea, 17.07.2013
95
US 8,524,674
Method of improving the conditioned reflex habit, the muscle tonus, or the motion coordination of a patient after suffering trauma to the brain cortex.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
USA 03.09.2013
96
UA 104981
Пептидна фармацевтична композицiя, засiб на її основi для лiкування гастродуоденальних захворювань, якi викликаються Helicobacter pylori, i спосiб його використання. (Peptide pharmaceutical composition, means for treatment of Helicobacter pylori induced gastroduodenal diseases on the basis thereof, and a method of use thereof.)
Khavinson V.Kh. Kvetnoi I.M. Polyakova V.O. Ryzhak G.A. Kozlov L.V.
Ukraine, 25.03.2014
97
KR 10-1382947
Peptide substance revealing an immunogeroprotective effect, pharmaceutical composition on its base and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
South Korea, 01.04.2014
98
IL 194500
Peptide substance enhancing capillaries resistance, pharmaceutical composition on its base and the method of its application.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Israel, 01.05.2014
99
IL 194499
Peptide glutamyl-aspartyl-proline, pharmaceutical compositions comprising the peptide and uses of the peptide.
Khavinson V.Kh. Grigoriev E.I. Malinin V.V. Ryzhak G.A.
Israel, 31.01.2015
100
ЕА 021849
Therapeutic application of Peptide Pharmaceutical Composition for medical treatment of gastroduodenal disorders, caused by Helicobacter pylori.
Khavinson V.Kh. Kvetnoi I.М. Polyakova V.О. Ryzhak G.А. Kozlov L.V.
Eurasia, 30.09.2015
101
EP 2667887
Pharmaceutical composition comprising the peptide Glu-Asp-Gly and use for treating. Helicobacter pylori induced gastroduodenal diseases.
Khavinson V.Kh. Kvetnoi I.M. Polyakova V.O. Ryzhak G.A. Kozlov L.V.
European patent, 16.12.2015